Could Gut Health Be Contributing to Your Fertility Struggles?

fertility gut heath

What about a leaky gut?

Leaky gut, also known as intestinal permeability, is a condition in which the lining of the small intestine gets inflamed, allowing undigested food particles, toxins, and microbes to enter circulation. Normally, the gut lining is selectively permeable, allowing nutrients to be absorbed while blocking the passage of unwanted substances. When the gut lining is injured, the tight connections between the cells become more porous, allowing bigger molecules to flow through. This can create an immunological response and persistent inflammation throughout the body, resulting in a variety of symptoms such as abdominal pain, bloating, exhaustion, skin problems, and autoimmune illnesses. Numerous things, including a poor diet, ongoing stress, gastrointestinal infections, and specific drugs, can contribute to a leaky gut. The gut has to be healed to support your general health and wellness.


Why is gut microbiome relevant to one's fertility health?

The community of microbes that inhabit the digestive tract, or the gut microbiome, is crucial for many aspects of our health, including fertility. Imbalances in the gut microbiome, such as an overgrowth of harmful bacteria or a lack of diversity in helpful bacteria, have been found in studies to have a negative impact on reproductive health.

By altering hormone levels, controlling inflammation, and modifying the immune system, the gut microbiome has an impact on fertility. Estrogen levels can actually be impacted by the gut microbiome. The production of an enzyme that aids in the metabolism of estrogen and the regulation of the activity of genes involved in estrogen signaling are two ways that the gut microbiota might affect estrogen levels. Short-chain fatty acids, which have anti-inflammatory properties and may aid in preventing oxidative stress, which is connected to fertility challenges, are also produced by a few helpful bacteria in the gut.

Imbalances in the gut microbiome have been linked to a range of fertility issues, including polycystic ovary syndrome (PCOS), endometriosis, and male infertility. Improving gut health through dietary changes, probiotics, and other interventions may help improve fertility outcomes. Therefore, maintaining a healthy gut microbiome is an important aspect of improving fertility.


Studies that correlate leaky gut and healthy microbiome to optimized fertility 

There is rising evidence to support the hypothesis that a healthy gut microbiome and a well-functioning intestinal barrier (i.e., no leaky gut) are essential in optimizing reproductive health. Here are a few examples of research studies::


  1. A 2017 study published in the journal Microbial Cell Factories discovered that supplementing with a probiotic strain of Lactobacillus rhamnosus GG enhanced reproductive results in women undergoing in vitro fertilization (IVF). The probiotic therapy was connected to a decline in intestinal inflammation markers, according to the study.
  2. According to a 2019 study published in the Journal of Assisted Reproduction and Genetics, dysbiosis (an imbalance in the gut microbiota) and leaky gut have been associated with a variety of reproductive problems, including endometriosis, PCOS, and male infertility. The review's authors found that "there is strong evidence supporting the role of gut microbiota in reproductive health and disease."
  3. Research published in the journal Fertility and Sterility in 2020 discovered that women with endometriosis had altered gut flora and increased intestinal permeability (i.e., leaky gut) compared to healthy controls. Interventions focused on enhancing gut health, according to the study's authors, may be a promising method for controlling endometriosis-related infertility.
  4. A 2021 research published in the journal Human Reproduction discovered that women with a larger diversity of gut flora had improved reproductive results following IVF. The study also discovered that women with a more diversified gut flora had greater levels of anti-Mullerian hormone (AMH), a sign of ovarian reserve.


Ways to optimize gut health to avoid leaky gut and improve fertility health

There are various strategies to enhance gut health and lower the chance of having a leaky gut, which may improve reproductive health. Here are a few ideas:


  1. Consume a nutrient-dense, well-balanced diet: A diet strong in fiber, whole foods, and fermented foods (such as yogurt, kefir, and sauerkraut) can support healthy gut microbiota and lower inflammation in the gut. Avoid overly processed meals, refined sugars, and artificial additives, which can harm the lining of the stomach.
  2. Consume a high-quality probiotic supplement: Probiotics are helpful bacteria that can aid in the maintenance of healthy gut microbiota. Identifying the right probiotic for you and a high-quality one should be specific to each individual.  In general, look for a probiotic supplement with a wide strain mix and a large number of colony-forming units (CFUs), but this is a place where personalized medicine is very important!
  3. Manage stress: Chronic stress can upset the equilibrium of microorganisms in the gut, leading to inflammation. Yoga, meditation, deep breathing, and spending time in nature are all stress-relieving strategies.
  4. Get regular exercise: Exercise can help promote a healthy gut microbiome and reduce inflammation. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
  5. Limit exposure to toxins: Toxins such as pesticides, heavy metals, and environmental pollutants can damage the intestinal lining and disrupt the gut microbiome. Try to limit exposure to these toxins by choosing organic produce, avoiding plastic containers and bottles, and using natural cleaning products.
  6. Avoid unnecessary medications: Antibiotics and even NSAIDs like Ibuprofen can disrupt the gut lining and the gut microbiome.  
  7. Consider working with a functional medicine practitioner: A functional medicine practitioner like Holistic Fertility Institute can help you identify any underlying factors that may be contributing to a leaky gut and develop a personalized plan to support gut health and optimize fertility.


While additional study is required to completely understand the intricate connections between gut microbiota, intestinal barrier function, and reproductive health, current data and our clinical experience show that enhancing gut health may be a significant element of fertility care. By implementing these strategies, you can help support a healthy gut microbiome and reduce the risk of developing a leaky gut.  Reach out to us for support if you feel your gut health needs help!